Thursday, February 11, 2010

Find a protein using PDB explorer - describe your protein, including what disease state or other real-world application it has.

Utilizing the key word diabetes in the pdblite.org the site provided an article with a protein. The code associated with the protein is 1kzw. It is described as the human intestinal fatty acid binding protein which binds lipids in the cytosol of enterocytes. It is a naturally occurring nucleotide polymorphism.
This protein exhibits secondary traits of helixes and pleated sheets (visualized as green crayons and tan arrows respectively on diagram). It has no subunits and therefore no quaternary traits.
The amino acid sequence would be useful for research in comparing the structure and function of one sequence to that of another. Similar sequences may combine, react, substitute in the same way therefore allowing for predictions of unknown or underresearched sequences.

On the pdblite.org site two views of the molecule are available. The all atoms shows the entire molecule including side chains whereas the backbone view does not show the side chains.

No comments:

Post a Comment